I've done a lot of reading and from what I've seen the "bad" tranny stories are usually routed in the fact that Dodge forgot to tell anyone (owners and lube shops) that you HAVE to use at least ATF +3 preferably ATF +4 in the autos or they will burn up. Normal ATF can not take the temperatures that the full synthetic +3 and +4 can.
As for the NV4500 (5 speed) what always took those out was people leaving them in 5th in town (down into the 20~30mph range) because they were too lazy to shift, the Cummins was fine with the ratio but the trans isn't fine with the torque.
The NV5600 (6 speed) was the only way you could get the HO's, it is a MUCH stronger (and bigger) trans.
From what I understand, when they came out with the new body style ALL of the transmissions got replaced with Germany ones.