My brother and his family are die hard Ford fans. About 12 or 13 years ago we had to move some construction equpment around. Nothing too major just the job site trailer, tools, that kind of thing, no equipment. I was driving my pop's 1997 Ford F-250 with a 460, 5 speed manual tranny and my brother was driving his 2000 F-250 with the V-10 and manual tranny. The 460 was an extra cab with a short bed, 4x4 and the V-10 was a standard cab with a long bed, 4x4. Not quite apples to apples but, as close as we had. My brother would run away from me on everything. I don't know if the trailer weights were the same or anything either but, I think they were close enough. The 460 is still around and the V-10 has long been let go. The V-10 engines had some issues spitting spark plugs out of the heads.
The 460 is a 10 mpg truck. I dont think that it will differ much between loaded or empty. I have only driven the truck about 1000 miles but, empty, loaded, towing, it does not matter much. Figure on 10 mpg. The extra cabs in the OBS are small. Very small by todays standards. They are good trucks but, try and find the 350 instead of the 250. The 250 has that funky twin traction beam front end that is a little hard on front tires. As the front springs begin to sag the tops of the tires start to point towards the engine. It will wear the inside of the tires when it foes happen. Heavy duty grille guards, winches, snow plows, will accelerate the wear.
I will agree that for what they are the 460 is relaible. They do seem to leak, at least my pops does, so when it quits leaking add a quart or two. Great engines, poor mileage, leaky, but, will always start and run. Not much power compared to todays standards but, a real work horse, jack of all trades, master of none.
LT.